Full name: glutamate ionotropic receptor AMPA type subunit 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: GLUR-C; GLUR-K3; GLUR3; GLURC; GluA3; MRX94; MRXSW; iGluR3

Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]

Expression: Biased expression in brain (RPKM 19.9), adrenal (RPKM 3.0) and 1 other tissue

Gene size: 306638bp

Exon count: 19