Full name: serpin family F member 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: A2AP; AAP; ALPHA-2-PI; API; PLI; alpha2AP

Summary: This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Expression: Biased expression in liver (RPKM 275.1) and kidney (RPKM 42.8)

Gene size: 12395bp

Exon count: 12