Full name: lymphoid enhancer binding factor 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: LEF-1; TCF10; TCF1ALPHA; TCF7L3

Summary: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Expression: Broad expression in lymph node (RPKM 17.6), appendix (RPKM 8.1) and 14 other tissues

Gene size: 121385bp

Exon count: 15