Full name: lymphoid enhancer binding factor 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 3000002B05; Lef-1

Summary: Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of gamma-delta T cell differentiation; and secondary palate development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in thymus adult (RPKM 63.3), spleen adult (RPKM 14.2) and 8 other tissues

Gene size: 114061bp

Exon count: 14