Full name: deleted in liver cancer 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: A730069N07Rik; Arhgap7; HP; STARD12; dlc-1

Summary: Predicted to enable several functions, including GTPase activator activity; SH2 domain binding activity; and phospholipase binding activity. Acts upstream of or within several processes, including actin cytoskeleton organization; focal adhesion assembly; and nervous system development. Predicted to be located in several cellular components, including caveola; cortical actin cytoskeleton; and ruffle membrane. Predicted to be active in focal adhesion and membrane raft. Predicted to colocalize with actin filament and stress fiber. Is expressed in several structures, including central nervous system; liver; mandible; placenta; and trigeminal nerve. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in lung adult (RPKM 9.5), subcutaneous fat pad adult (RPKM 8.0) and 24 other tissues

Gene size: 385451bp

Exon count: 26