Full name: DLC1 Rho GTPase activating protein

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ARHGAP7; HP; STARD12; p122-RhoGAP

Summary: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Expression: Broad expression in lung (RPKM 21.4), fat (RPKM 12.0) and 21 other tissues

Gene size: 521260bp

Exon count: 24