Full name: neurotrophic receptor tyrosine kinase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA

Summary: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Expression: Biased expression in adrenal (RPKM 3.7), testis (RPKM 1.0) and 10 other tissues

Gene size: 66101bp

Exon count: 19