Full name: neurotrophic tyrosine kinase, receptor, type 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Tkr; TrkA; trk

Summary: Predicted to enable several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and nerve growth factor receptor activity. Involved in axonogenesis involved in innervation; negative regulation of neuron apoptotic process; and sympathetic nervous system development. Acts upstream of or within several processes, including behavioral response to formalin induced pain; nerve growth factor signaling pathway; and nervous system development. Located in axon; cell surface; and endosome. Is expressed in several structures, including branchial arch; gonad; nervous system; sensory organ; and urogenital ridge. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in adrenal adult (RPKM 7.1), CNS E14 (RPKM 2.8) and 13 other tissues

Gene size: 16999bp

Exon count: 18