Full name: nuclear factor of activated T cells 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: NF-ATC; NF-ATc1.2; NFAT2; NFATc

Summary: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

Expression: Broad expression in lymph node (RPKM 7.4), spleen (RPKM 6.0) and 24 other tissues

Gene size: 133394bp

Exon count: 11