Full name: afadin, adherens junction formation factor

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AF6; MLL-AF6; MLLT4; l-afadin

Summary: This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]

Expression: Ubiquitous expression in esophagus (RPKM 18.5), lung (RPKM 15.9) and 24 other tissues

Gene size: 145460bp

Exon count: 35