Afdn afadin, adherens junction formation factor [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 17356)
Source: NCBI Gene (ID 17356)
Symbol: Afdn
Full name: afadin, adherens junction formation factor
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 5033403D15Rik; AF6; Af-6; Afadin; Gm314; I-afadin; Mllt4; S-afadin
Summary: Enables cell adhesion molecule binding activity. Involved in cell-cell adhesion mediated by cadherin; establishment of protein localization to plasma membrane; and pore complex assembly. Acts upstream of or within several processes, including adherens junction maintenance; nervous system development; and regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including adherens junction; apical junction complex; and apical part of cell. Part of pore complex. Is expressed in eye; genitourinary system; and nervous system. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 14.2), whole brain E14.5 (RPKM 13.1) and 28 other tissues
Orthologs: human
Gene size: 145325bp
Exon count: 34