Full name: inositol 1,4,5-trisphosphate receptor type 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CMT1J; IP3R; IP3R3

Summary: This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

Expression: Broad expression in thyroid (RPKM 29.7), skin (RPKM 28.2) and 22 other tissues

Gene size: 75241bp

Exon count: 62