Full name: APC regulator of WNT signaling pathway

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BTPS2; DESMD; DP2; DP2.5; DP3; GS; PPP1R46

Summary: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022]

Expression: Ubiquitous expression in brain (RPKM 25.7), colon (RPKM 4.5) and 23 other tissues

Gene size: 138742bp

Exon count: 20