Full name: APC, WNT signaling pathway regulator

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CC1; Min; mAPC

Summary: Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues

Gene size: 101894bp

Exon count: 19