Full name: drosha ribonuclease III

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN

Summary: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

Expression: Ubiquitous expression in brain (RPKM 9.5), ovary (RPKM 7.6) and 25 other tissues

Gene size: 131600bp

Exon count: 36