Full name: Rho GTPase activating protein 35

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: GRF-1; GRLF1; P190-A; P190A; p190ARhoGAP; p190RhoGAP

Summary: The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]

Expression: Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues

Gene size: 144081bp

Exon count: 9