Full name: R-spondin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CRISTIN3; RSPO

Summary: This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Expression: Biased expression in endometrium (RPKM 16.2), skin (RPKM 2.3) and 5 other tissues

Gene size: 23543bp

Exon count: 8