Full name: sestrin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: PA26; SEST1

Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Expression: Ubiquitous expression in testis (RPKM 26.4), ovary (RPKM 22.9) and 25 other tissues

Gene size: 110538bp

Exon count: 12