Full name: sestrin 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 1110002G11Rik; Pa26; Sest1

Summary: Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in cellular response to amino acid stimulus; negative regulation of TORC1 signaling; and negative regulation of cell growth. Acts upstream of or within regulation of protein kinase B signaling. Predicted to be located in cytoplasm; fibrillar center; and nucleoplasm. Predicted to be part of GATOR2 complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SESN1 (sestrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in heart adult (RPKM 16.1), large intestine adult (RPKM 14.7) and 28 other tissues

Gene size: 97863bp

Exon count: 11