Iqsec2 IQ motif and Sec7 domain 2 [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 245666)
Source: NCBI Gene (ID 245666)
Symbol: Iqsec2
Full name: IQ motif and Sec7 domain 2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: Brag1
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization; modulation of chemical synaptic transmission; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in presynaptic active zone cytoplasmic component. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and postsynaptic density. Is expressed in brain. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 7.5), adrenal adult (RPKM 7.1) and 22 other tissues
Orthologs: human
Gene size: 81055bp
Exon count: 17