Full name: IQ motif and Sec7 domain ArfGEF 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BRAG1; IQ-ArfGEF; MRX1; MRX18; MRX78; XLID1

Summary: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Expression: Ubiquitous expression in brain (RPKM 5.1), adrenal (RPKM 1.4) and 23 other tissues

Gene size: 95538bp

Exon count: 22