Full name: phospholipase D family member 3

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: AD19; HU-K4; HUK4; SCA46

Summary: This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]

Expression: Ubiquitous expression in brain (RPKM 96.3), spleen (RPKM 74.5) and 25 other tissues

Gene size: 29791bp

Exon count: 15