KDM4B lysine demethylase 4B [ Homo sapiens (human) ]
Source: NCBI Gene (ID 23030)
Source: NCBI Gene (ID 23030)
Symbol: KDM4B
Full name: lysine demethylase 4B
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Also known as: JMJD2B; MRD65; TDRD14B
Summary: Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in prostate (RPKM 5.2), thyroid (RPKM 5.0) and 25 other tissues
Orthologs: mouse
Gene size: 184486bp
Exon count: 33