Kdm4b lysine (K)-specific demethylase 4B [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 193796)
Source: NCBI Gene (ID 193796)
Symbol: Kdm4b
Full name: lysine (K)-specific demethylase 4B
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: 4732474L06Rik; Jmjd2b
Summary: Enables histone H3-methyl-lysine-9 demethylase activity. Acts upstream of or within histone H3-K36 demethylation; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Located in pericentric heterochromatin. Is expressed in several structures, including early conceptus; genitourinary system; heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Orthologous to human KDM4B (lysine demethylase 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 19.4), ovary adult (RPKM 19.2) and 28 other tissues
Orthologs: human
Gene size: 77800bp
Exon count: 23