Full name: calsyntenin 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: ALC-ALPHA; CDHR12; CST-1; CSTN1; PIK3CD; XB31alpha; alcalpha1; alcalpha2

Summary: This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Expression: Ubiquitous expression in brain (RPKM 135.7), skin (RPKM 44.9) and 23 other tissues

Gene size: 95601bp

Exon count: 19