Full name: tet methylcytosine dioxygenase 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Ayu17-449; E130014J05Rik; mKIAA1546

Summary: Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in frontal lobe adult (RPKM 4.9), CNS E11.5 (RPKM 4.5) and 28 other tissues

Gene size: 81445bp

Exon count: 14