Full name: AKT serine/threonine kinase 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA

Summary: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]

Expression: Ubiquitous expression in thyroid (RPKM 30.9), fat (RPKM 28.8) and 25 other tissues

Gene size: 55029bp

Exon count: 23