Full name: thymoma viral proto-oncogene 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 2410016A19Rik; PKB; PKBbeta

Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to insulin stimulus; intracellular protein transmembrane transport; and positive regulation of transport. Acts upstream of or within with a negative effect on protein localization to nucleus. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and peripheral nervous system myelin maintenance. Located in cell cortex and ruffle membrane. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; retina; and spleen. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; hypoinsulinemic hypoglycemia with hemihypertrophy; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 40.3), mammary gland adult (RPKM 35.7) and 28 other tissues

Gene size: 49275bp

Exon count: 21