Full name: epoxide hydrolase 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: EPHX; EPOX; HYL1; MEH

Summary: Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]

Expression: Broad expression in liver (RPKM 307.4), adrenal (RPKM 287.9) and 19 other tissues

Gene size: 35440bp

Exon count: 11