Sel1l sel-1 suppressor of lin-12-like (C. elegans) [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 20338)
Source: NCBI Gene (ID 20338)
Symbol: Sel1l
Full name: sel-1 suppressor of lin-12-like (C. elegans)
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Also known as: Sel1h; mKIAA4137
Summary: Predicted to contribute to ubiquitin-protein transferase activity. Involved in ERAD pathway; protein secretion; and triglyceride metabolic process. Acts upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Is expressed in several structures, including genitourinary system; liver; neural tube; pancreas; and spleen. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 18.7), cortex adult (RPKM 16.8) and 28 other tissues
Orthologs: human
Gene size: 43115bp
Exon count: 21