Full name: paired related homeobox 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: A230024N07Rik; K-2; MHox1; Pmx; Pmx1; Prx1; mHox

Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; neuronal stem cell population maintenance; and positive regulation of smoothened signaling pathway. Located in nucleus. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to human PRRX1 (paired related homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in limb E14.5 (RPKM 22.0), CNS E11.5 (RPKM 6.8) and 8 other tissues

Gene size: 70027bp

Exon count: 6