Full name: phospholipase C, beta 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 3110043I21Rik; Plcb; mKIAA0581

Summary: Enables lamin binding activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of cellular macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Located in several cellular components, including chromatin; glutamatergic synapse; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (phospholipase C beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 8.8) and 13 other tissues

Gene size: 689095bp

Exon count: 35