Full name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 2410099E07Rik; 2610208K16Rik; p110delta

Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in positive regulation of angiogenesis and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including B cell activation; B cell homeostasis; and defense response to fungus. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in early embryo; hemolymphoid system; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in spleen adult (RPKM 42.3), thymus adult (RPKM 28.3) and 18 other tissues

Gene size: 53399bp

Exon count: 32