DOCK1 dedicator of cytokinesis 1 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 1793)
Source: NCBI Gene (ID 1793)
Symbol: DOCK1
Full name: dedicator of cytokinesis 1
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: DOCK180; ced5
Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression: Ubiquitous expression in thyroid (RPKM 10.9), skin (RPKM 10.0) and 24 other tissues
Orthologs: mouse
Gene size: 547089bp
Exon count: 60