Full name: Kruppel-like factor 1 (erythroid)

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Eklf; Nan

Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in erythrocyte differentiation; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including chromatin remodeling; hemopoiesis; and liver development. Predicted to be located in chromatin and nucleoplasm. Is expressed in several structures, including extraembryonic component; hemolymphoid system; olfactory placode; testis; and urethra. Used to study beta thalassemia and hereditary spherocytosis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (Kruppel like factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in liver E14.5 (RPKM 150.9), liver E14 (RPKM 122.7) and 2 other tissues

Gene size: 3310bp

Exon count: 3