Full name: growth arrest and DNA damage inducible alpha

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DDIT1; GADD45

Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Expression: Broad expression in liver (RPKM 72.1), kidney (RPKM 57.9) and 23 other tissues

Gene size: 3134bp

Exon count: 4