Full name: insulin receptor substrate 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: G972R; IRS-1

Summary: Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in cellular response to fatty acid. Acts upstream of or within several processes, including cellular response to insulin stimulus; positive regulation of phosphatidylinositol 3-kinase activity; and protein kinase B signaling. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (insulin receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in ovary adult (RPKM 15.6), subcutaneous fat pad adult (RPKM 14.2) and 20 other tissues

Gene size: 58335bp

Exon count: 2