Full name: DAB adaptor protein 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DOC-2; DOC2

Summary: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Expression: Broad expression in placenta (RPKM 111.0), kidney (RPKM 73.8) and 20 other tissues

Gene size: 53304bp

Exon count: 15