Full name: disabled 2, mitogen-responsive phosphoprotein

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: 5730435J12Rik; D15Wsu122e; D630005B22Rik; Doc-2; Doc2; p96

Summary: Enables several functions, including AP-2 adaptor complex binding activity; clathrin adaptor activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including endocytosis; hemopoiesis; and negative regulation of extrinsic apoptotic signaling pathway. Located in apical plasma membrane; cytoplasm; and nucleus. Part of clathrin coat of coated pit. Is expressed in several structures, including central nervous system; egg cylinder; embryo mesenchyme; future hindbrain roof plate; and metanephros. Orthologous to human DAB2 (DAB adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in kidney adult (RPKM 58.2), placenta adult (RPKM 56.8) and 17 other tissues

Gene size: 140928bp

Exon count: 18