Full name: cytochrome b-245 alpha chain

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: CGD4; p22-PHOX

Summary: Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

Expression: Broad expression in bone marrow (RPKM 72.4), spleen (RPKM 55.1) and 18 other tissues

Gene size: 7765bp

Exon count: 6