Full name: cytochrome b-245, alpha polypeptide

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: b558; nmf333; p22-phox; p22phox

Summary: Predicted to enable SH3 domain binding activity; electron transfer activity; and protein heterodimerization activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in innate immune response. Acts upstream of or within positive regulation of mucus secretion; reactive oxygen species metabolic process; and regulation of release of sequestered calcium ion into cytosol. Located in endosome. Part of NADPH oxidase complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; inner ear; limb; and liver. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Broad expression in kidney adult (RPKM 399.2), spleen adult (RPKM 288.4) and 19 other tissues

Gene size: 8170bp

Exon count: 6