Full name: lysophosphatidic acid receptor 1

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: Edg2; Gpcr26; Kdt2; lpA1; vzg-1

Summary: Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Ubiquitous expression in limb E14.5 (RPKM 20.9), colon adult (RPKM 17.1) and 24 other tissues

Gene size: 119350bp

Exon count: 16