Full name: essential meiotic structure-specific endonuclease 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: MMS4L; SLX2A

Summary: This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Expression: Broad expression in testis (RPKM 5.3), bone marrow (RPKM 3.4) and 25 other tissues

Gene size: 8255bp

Exon count: 10