Full name: carboxypeptidase E

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BDVS; CPH; IDDHH

Summary: This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]

Expression: Biased expression in brain (RPKM 491.8), prostate (RPKM 192.3) and 11 other tissues

Gene size: 119540bp

Exon count: 9