Full name: carboxypeptidase E

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CPH; Cph-1; Cph1; NF-alpha1; fat

Summary: This gene encodes carboxypeptidase E, a prohormone-processing exopeptidase found in secretory granules of endocrine and neuroendocrine cells. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that cleaves the C-terminal basic residues of protein substrates. A missense mutation in this gene is responsible for the obesity phenotype in a mouse model known as the "fat mouse." Mice lacking the functional product of this gene exhibit impaired processing of multiple peptide hormones such as proinsulin, prodynorphin, proneurotensin, promelanin-concentrating hormone and pro-opiomelanocortin. [provided by RefSeq, Jan 2016]

Expression: Biased expression in frontal lobe adult (RPKM 416.8), cortex adult (RPKM 400.4) and 14 other tissues

Gene size: 100568bp

Exon count: 9