Full name: cathepsin E

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: A430072O03Rik; C920004C08Rik; CE; CatE

Summary: This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]

Expression: Biased expression in stomach adult (RPKM 438.1), bladder adult (RPKM 70.7) and 3 other tissues

Gene size: 37194bp

Exon count: 10