Full name: C-C motif chemokine receptor 7

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1

Summary: The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Expression: Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues

Gene size: 11704bp

Exon count: 5