Full name: bradykinin receptor, beta 2

Gene type: protein coding

RefSeq status: VALIDATED

Also known as: B(2); B2; B2R; BK-2; BK2; BK2R; BKR2; BRB2

Summary: Predicted to enable several functions, including G protein-coupled receptor binding activity; bradykinin receptor activity; and protein heterodimerization activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; and vasodilation. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Is expressed in collecting duct and metanephros. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2). [provided by Alliance of Genome Resources, Apr 2022]

Expression: Biased expression in colon adult (RPKM 5.2), subcutaneous fat pad adult (RPKM 3.2) and 14 other tissues

Gene size: 32073bp

Exon count: 5