Add1 adducin 1 (alpha) [ Mus musculus (house mouse) ]
Source: NCBI Gene (ID 11518)
Source: NCBI Gene (ID 11518)
Symbol: Add1
Full name: adducin 1 (alpha)
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Summary: A structural constituent of cytoskeleton. Involved in cellular response to calcium ion; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Acts upstream of or within several processes, including cell volume homeostasis; erythrocyte differentiation; and hemoglobin metabolic process. Located in adherens junction; cytoskeleton; and membrane. Colocalizes with plasma membrane. Is expressed in brown fat; cerebellum; and spleen. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 54.1), cortex adult (RPKM 53.6) and 28 other tissues
Orthologs: human
Gene size: 58645bp
Exon count: 20