EGLN3 egl-9 family hypoxia inducible factor 3 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 112399)
Source: NCBI Gene (ID 112399)
Symbol: EGLN3
Full name: egl-9 family hypoxia inducible factor 3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Also known as: HIFP4H3; HIFPH3; PHD3
Summary: Enables peptidyl-proline 4-dioxygenase activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and response to hypoxia. Located in cytosol and nucleus. Implicated in renal cell carcinoma. Biomarker of clear cell renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in skin (RPKM 31.3), heart (RPKM 27.7) and 16 other tissues
Orthologs: mouse
Gene size: 26848bp
Exon count: 5